BEX4

Across TCGA patient cohorts, BEX4 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEX4-associated genes across cancer lineages are eIF4E, 4E-BP1, and 14-3-3_beta. Each is linked with BEX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEX4-to-partner and partner-to-BEX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by BEX4-low versus BEX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEX4→partner) and Y-score (partner→BEX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.170	+2.087	.035	.005	3	2
UCEC	4E-BP1 →	+0.326	+2.087	.001	.005	3	2
UCEC	14-3-3_beta →	-0.087	-2.295	.023	.033	3	1
UCEC	GAPDH →	+0.492	+1.807	.016	.025	3	1
UCEC	GATA6 →	-0.178	-3.307	.004	.009	3	1
UCEC	INPP4B →	-0.292	-2.700	.018	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by BEX4 expression — UCEC

Explore this box plot interactively →