BEX1

Across TCGA patient cohorts, BEX1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEX1-associated genes across cancer lineages are PCNA, INPP4B, and MSH2. Each is linked with BEX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEX1-to-partner and partner-to-BEX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by BEX1-low versus BEX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEX1→partner) and Y-score (partner→BEX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.247	+2.700	.011	.006	3	2
UCEC	INPP4B →	-0.359	-2.459	.013	.019	3	1
UCEC	MSH2 →	-0.334	-3.295	.001	.009	3	1
UCEC	MSH6 →	-0.392	-2.999	.008	.035	3	1
UCEC	mTOR_pS2448 →	-0.172	-3.308	.010	.009	3	1
UCEC	Notch1 →	+0.137	+2.820	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PCNA by BEX1 expression — UCEC

Explore this box plot interactively →