BET1

Across TCGA patient cohorts, BET1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BET1-associated genes across cancer lineages are Caspase-7-cleavedD198, STAT3_pY705, and VHL. Each is linked with BET1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BET1-to-partner and partner-to-BET1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by BET1-low versus BET1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BET1→partner) and Y-score (partner→BET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.657	+3.019	.044	.019	3	2
UCEC	STAT3_pY705 →	-0.485	-3.169	<.001	.020	3	1
UCEC	VHL →	-0.783	-3.000	.035	.036	3	1
UCEC	PCNA →	+0.288	+3.169	.015	.020	2	1
UCEC	MEK1 →	+0.607	+3.169	.002	.020	1	1
UCEC	Notch1 →	+0.215	+3.169	.005	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Caspase-7-cleavedD198 by BET1 expression — UCEC

Explore this box plot interactively →