BEST3

Across TCGA patient cohorts, BEST3 mutation is significantly associated with the RNA expression of many other genes, with 2,057 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEST3-associated genes across cancer lineages are RNU1-17P, RNA5SP516, and RNU2-39P. Each is linked with BEST3 in more than 2 cancer types. Because this analysis shows association rather than direction, both BEST3-to-partner and partner-to-BEST3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by BEST3-low versus BEST3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST3→partner) and Y-score (partner→BEST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU1-17P →	+0.691	+3.252	<.001	.009	3	3
STAD	RNA5SP516 →	+0.653	+3.499	<.001	.005	3	3
STAD	RNU2-39P →	+0.858	+3.666	<.001	.007	3	3
LUAD	AUP1 →	+0.429	+3.345	.001	.005	3	3
CESC	ADIPOR1P1 →	+0.037	+3.064	.001	.007	3	3
UCEC	DTYMK →	+0.578	+2.201	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,057 associations by consensus.

RNU1-17P by BEST3 expression — STAD

Explore this box plot interactively →