BEST3

Across TCGA patient cohorts, BEST3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEST3-associated genes across cancer lineages are PCNA, EGFR_pY1068, and FoxM1. Each is linked with BEST3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEST3-to-partner and partner-to-BEST3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by BEST3-low versus BEST3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST3→partner) and Y-score (partner→BEST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.214	+2.169	.008	.003	3	2
UCEC	EGFR_pY1068 →	-0.263	-1.765	.005	.014	3	1
UCEC	FoxM1 →	+0.208	+1.765	.031	.014	3	1
UCEC	HER2_pY1248 →	-0.207	-2.662	.039	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.156	-2.000	.013	.030	3	1
UCEC	Rab25 →	-0.285	-1.415	.022	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PCNA by BEST3 expression — UCEC

Explore this box plot interactively →