BEST3

Across TCGA cell cohorts, BEST3 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BEST3-associated genes across cancer lineages are ADGRA1, C14orf178, and VCY1B. Each is linked with BEST3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEST3-to-partner and partner-to-BEST3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADGRA1 grouped by BEST3-low versus BEST3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST3→partner) and Y-score (partner→BEST3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADGRA1 →	+0.004	+2.925	<.001	.007	3	1
SKIN	C14orf178 →	+0.122	+4.013	.001	.001	3	1
OVARY	VCY1B →	+0.275	+4.029	<.001	.009	3	1
OVARY	VCY →	+0.278	+4.228	<.001	.006	3	1
OVARY	GP9 →	+0.035	+4.029	<.001	.009	3	1
LARGE_INTESTINE	MS4A4A →	+0.147	+2.678	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ADGRA1 by BEST3 expression — SKIN

Explore this box plot interactively →