BEST2

Across TCGA patient cohorts, BEST2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,776 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BEST2-associated genes across cancer lineages are DDR2, EFEMP1, and SVEP1. Each is linked with BEST2 in more than 4 cancer types. Because this analysis shows association rather than direction, both BEST2-to-partner and partner-to-BEST2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BEST2 versus DDR2 in UCEC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST2→partner) and Y-score (partner→BEST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DDR2 →	+0.720	+0.480	.002	.002	3	5
UCEC	EFEMP1 →	+1.536	+0.773	.001	.001	3	4
UCEC	SVEP1 →	+0.951	+1.006	.002	<.001	3	4
UCEC	CD34 →	+0.755	+0.755	<.001	.001	3	4
UCEC	MEF2C →	+0.546	+0.501	.001	.001	3	4
CCRCC	SSPN →	+0.600	+0.443	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,776 associations by consensus.

BEST2 vs DDR2 — UCEC

Explore this scatter interactively →