BEST2

Across TCGA patient cohorts, BEST2 mutation is significantly associated with the RNA expression of many other genes, with 2,437 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEST2-associated genes across cancer lineages are RNU6-442P, LINC02330, and MIR548AW. Each is linked with BEST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEST2-to-partner and partner-to-BEST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-442P grouped by BEST2-low versus BEST2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST2→partner) and Y-score (partner→BEST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU6-442P →	+0.556	+4.669	<.001	.001	3	2
STAD	LINC02330 →	+0.119	+3.646	.006	.009	3	2
CESC	MIR548AW →	+0.402	+4.837	<.001	.003	3	2
CESC	MIR7976 →	+0.543	+3.269	.001	.008	3	2
UCEC	PHF5A →	+0.621	+3.247	<.001	<.001	3	2
UCEC	POLE2 →	+0.586	+2.716	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,437 associations by consensus.

RNU6-442P by BEST2 expression — STAD

Explore this box plot interactively →