BEST2

Across TCGA patient cohorts, BEST2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEST2-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and eIF4E. Each is linked with BEST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEST2-to-partner and partner-to-BEST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by BEST2-low versus BEST2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST2→partner) and Y-score (partner→BEST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.926	+2.479	<.001	.010	3	2
UCEC	14-3-3_beta →	-0.100	-1.687	.019	.044	3	1
UCEC	eIF4E →	+0.183	+2.222	.040	.011	3	1
UCEC	MEK1 →	+0.365	+2.222	.018	.011	3	1
UCEC	Notch1 →	+0.271	+2.713	<.001	.003	3	1
UCEC	p62 Lck ligand →	+0.437	+2.710	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Caspase-7-cleavedD198 by BEST2 expression — UCEC

Explore this box plot interactively →