BEST2

Across TCGA cell cohorts, BEST2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,113 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible BEST2-associated GO terms across cancer lineages are Positive regulation of protein localization to nucleus, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Establishment of RNA localization. Each is linked with BEST2 in more than 6 cancer types. Because this analysis shows association rather than direction, both BEST2-to-partner and partner-to-BEST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to nucleus grouped by BEST2-low versus BEST2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST2→partner) and Y-score (partner→BEST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of protein localization to nucleus →	+0.064	+0.058	<.001	<.001	3	7
LUNG_SCLC	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.089	+0.146	.001	<.001	3	6
BONE	Establishment of RNA localization →	+0.102	+0.066	<.001	.005	3	6
LUNG_SCLC	Protein sumoylation →	+0.085	+0.157	<.001	<.001	3	6
PANCREAS	Regulation of protein localization to nucleus →	+0.067	+0.084	<.001	.002	2	6
UPPER_AERODIGESTIVE_TRACT	Hypoxia-inducible factor-1alpha signaling pathway →	-0.872	-0.796	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,113 associations by consensus.

Positive regulation of protein localization to nucleus by BEST2 expression — BONE

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