BEST2

Across TCGA cell cohorts, BEST2 mutation is significantly associated with the RNA expression of many other genes, with 82 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BEST2-associated genes across cancer lineages are SLC32A1, MMP27, and GPR101. Each is linked with BEST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEST2-to-partner and partner-to-BEST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by BEST2-low versus BEST2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST2→partner) and Y-score (partner→BEST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.754	+3.901	<.001	.006	3	1
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	GPR101 →	+0.108	+3.551	<.001	.009	3	1
BLOOD_Leukemia	MAGEC3 →	+0.211	+3.855	.006	.007	3	1
BLOOD_Leukemia	MORN5 →	+0.318	+3.855	<.001	.007	3	1
BLOOD_Leukemia	CYP4A11 →	+0.021	+3.705	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

SLC32A1 by BEST2 expression — BLOOD_Leukemia

Explore this box plot interactively →