BEND6

Across TCGA patient cohorts, BEND6 mutation is significantly associated with the RNA expression of many other genes, with 2,036 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEND6-associated genes across cancer lineages are GCN1, GOLGA3, and BTBD10. Each is linked with BEND6 in more than 2 cancer types. Because this analysis shows association rather than direction, both BEND6-to-partner and partner-to-BEND6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCN1 grouped by BEND6-low versus BEND6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEND6→partner) and Y-score (partner→BEND6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GCN1 →	+0.453	+2.616	.003	.005	3	3
UCEC	GOLGA3 →	+0.564	+3.884	<.001	<.001	3	3
UCEC	BTBD10 →	+0.479	+2.617	.001	.005	3	2
UCEC	C16orf87 →	+0.502	+2.609	.001	.005	3	2
UCEC	FANCC →	+0.416	+2.839	.003	.001	3	2
UCEC	ABHD3 →	+0.663	+3.721	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,036 associations by consensus.

GCN1 by BEND6 expression — UCEC

Explore this box plot interactively →