BEND5

Across TCGA patient cohorts, BEND5 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEND5-associated genes across cancer lineages are PRAS40_pT246, ASNS, and 14-3-3_beta. Each is linked with BEND5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEND5-to-partner and partner-to-BEND5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by BEND5-low versus BEND5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEND5→partner) and Y-score (partner→BEND5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAS40_pT246 →	+0.148	+3.169	.028	.019	3	2
UCEC	ASNS →	+0.705	+2.321	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.099	-1.847	.011	.049	3	1
UCEC	ERCC1 →	-0.148	-2.584	.029	.010	3	1
UCEC	p27_pT157 →	-0.062	-2.000	.006	.010	3	1
UCEC	p62 Lck ligand →	+0.373	+3.169	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PRAS40_pT246 by BEND5 expression — UCEC

Explore this box plot interactively →