BEND5

Across TCGA cell cohorts, BEND5 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible BEND5-associated genes across cancer lineages are DCD, DPRX, and CST11. Each is linked with BEND5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEND5-to-partner and partner-to-BEND5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCD grouped by BEND5-low versus BEND5-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEND5→partner) and Y-score (partner→BEND5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DCD →	+0.046	+4.643	<.001	.008	3	1
CNS	DPRX →	+0.068	+5.321	<.001	.005	3	1
LUNG_NSCLC_LUAD	CST11 →	+0.099	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PTH →	+0.031	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	FCN2 →	+0.394	+5.662	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

DCD by BEND5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →