BEND3

Across TCGA pan-cancer cohorts, BEND3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BEND3 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher BEND3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BEND3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where BEND3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.915	0.645	.001	38	view →
PDAC	OS	Quartile	II,III,IV	0.295	0.760	.015	9	view →
HNSC	OS	Tertile	All	0.631	0.847	.043	1	view →
LUAD	DFS	Quartile	All	0.907	0.974	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

BEND3–LSCC (OS)

Open the LSCC breakdown →