BEND3

Across TCGA patient cohorts, BEND3 mutation is significantly associated with the RNA expression of many other genes, with 3,466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEND3-associated genes across cancer lineages are SCO1, BNIP3L, and BCCIP. Each is linked with BEND3 in more than 2 cancer types. Because this analysis shows association rather than direction, both BEND3-to-partner and partner-to-BEND3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCO1 grouped by BEND3-low versus BEND3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEND3→partner) and Y-score (partner→BEND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCO1 →	+0.542	+2.818	<.001	<.001	3	3
UCEC	BNIP3L →	+0.609	+2.115	<.001	<.001	3	3
UCEC	BCCIP →	+0.419	+1.847	<.001	<.001	3	3
UCEC	RAD51C →	+0.468	+2.443	<.001	<.001	3	3
UCEC	NEK4 →	+0.483	+2.454	.002	<.001	3	3
UCEC	FBXO30 →	+0.352	+1.753	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,466 associations by consensus.

SCO1 by BEND3 expression — UCEC

Explore this box plot interactively →