BEND3

Across TCGA patient cohorts, BEND3 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEND3-associated genes across cancer lineages are Ku80, mTOR, and p90 RSK. Each is linked with BEND3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEND3-to-partner and partner-to-BEND3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by BEND3-low versus BEND3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEND3→partner) and Y-score (partner→BEND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Ku80 →	+0.316	+3.000	.029	.035	3	2
COAD	mTOR →	+0.210	+3.364	.030	.005	3	2
COAD	p90 RSK →	+0.314	+2.178	.011	.035	3	2
UCEC	ERK2 →	+0.262	+2.584	<.001	<.001	3	2
UCEC	NF2 →	+0.187	+2.115	.009	.016	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.379	-1.906	.011	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Ku80 by BEND3 expression — COAD

Explore this box plot interactively →