BEND2

Across TCGA cell cohorts, BEND2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible BEND2-associated genes across cancer lineages are OR4C12, REG1B, and IFITM5. Each is linked with BEND2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEND2-to-partner and partner-to-BEND2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4C12 grouped by BEND2-low versus BEND2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEND2→partner) and Y-score (partner→BEND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4C12 →	+0.020	+5.247	<.001	<.001	3	1
LARGE_INTESTINE	REG1B →	+2.191	+2.518	<.001	.006	3	1
LARGE_INTESTINE	IFITM5 →	+0.503	+3.847	<.001	.001	3	1
BLOOD_Leukemia	GUCA1C →	+0.039	+5.969	<.001	.001	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR4C12 by BEND2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →