BEND2

Across TCGA cell cohorts, BEND2 mutation is significantly associated with the mutation status of many other genes, with 2,518 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BEND2-associated genes across cancer lineages are MYCBP2, FIZ1, and ZNF471. Each is linked with BEND2 in more than 3 cancer types. Because this analysis shows association rather than direction, both BEND2-to-partner and partner-to-BEND2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYCBP2 grouped by BEND2-low versus BEND2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEND2→partner) and Y-score (partner→BEND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYCBP2 →	+2.340	+4.218	.001	.001	1	4
LARGE_INTESTINE	FIZ1 →	+2.146	+2.321	.008	.008	1	3
LARGE_INTESTINE	ZNF471 →	+3.954	+3.215	<.001	<.001	1	3
LARGE_INTESTINE	PIGN →	+2.632	+2.906	<.001	<.001	1	3
LUNG_NSCLC_LUAD	ZNRF4 →	+3.303	+3.478	.006	.006	1	3
LUNG_NSCLC_LUAD	AP3B1 →	+5.303	+4.339	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,518 associations by consensus.

MYCBP2 by BEND2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →