Across TCGA patient cohorts, BEGAIN mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEGAIN-associated genes across cancer lineages are FOXO3a, IRS1, and MEK1. Each is linked with BEGAIN in more than 1 cancer types. Because this analysis shows association rather than direction, both BEGAIN-to-partner and partner-to-BEGAIN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEGAIN→partner) and Y-score (partner→BEGAIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	+0.100	+1.713	.020	.027	3	1
UCEC	IRS1 →	+0.183	+1.700	.037	.044	3	1
UCEC	MEK1 →	+0.324	+1.700	.037	.044	3	1
UCEC	Myosin-IIa →	+0.167	+1.592	.039	.044	3	1
UCEC	Notch1 →	+0.219	+3.469	<.001	.002	3	1
UCEC	p62 Lck ligand →	+0.341	+2.222	.013	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

BEGAIN survival (RNA) · tumor vs normal (RNA) · all BEGAIN data types