Across TCGA cell cohorts, BEGAIN mutation is significantly associated with the RNA expression of many other genes, with 459 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BEGAIN-associated genes across cancer lineages are OR1M1, OCM2, and OR9Q1. Each is linked with BEGAIN in more than 1 cancer types. Because this analysis shows association rather than direction, both BEGAIN-to-partner and partner-to-BEGAIN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEGAIN→partner) and Y-score (partner→BEGAIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR1M1 →	+0.019	+5.209	<.001	.005	3	2
OVARY	OCM2 →	+1.398	+5.196	<.001	.005	3	1
OVARY	OR9Q1 →	+0.006	+5.807	<.001	.001	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.049	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP19-3 →	+0.132	+5.228	<.001	.005	3	1
LUNG_SCLC	FFAR3 →	+0.047	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 459 associations by consensus.

Exploration

BEGAIN survival (RNA) · tumor vs normal (RNA) · all BEGAIN data types