BECN1

Across TCGA pan-cancer cohorts, BECN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated BECN1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher BECN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BECN1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where BECN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.723	0.429	.010	8	view →
LUAD	DFS	Tertile	All	0.846	0.390	.011	8	view →
GBM	DFS	Tertile	All	0.273	0.414	.013	7	view →
LSCC	DFS	Quartile	III,IV	0.485	1.000	.016	6	view →
PDAC	DFS	Quartile	All	0.710	0.841	.029	5	view →
UCEC	DFS	Median	II,III,IV	0.826	1.000	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

BECN1–CCRCC (DFS)

Open the CCRCC breakdown →