BECN1

Across TCGA patient cohorts, BECN1 mutation is significantly associated with the RNA expression of many other genes, with 1,558 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BECN1-associated genes across cancer lineages are RNU6-99P, LINC02272, and LINC01248. Each is linked with BECN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BECN1-to-partner and partner-to-BECN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-99P grouped by BECN1-low versus BECN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BECN1→partner) and Y-score (partner→BECN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-99P →	+0.089	+3.812	<.001	.008	3	3
SKCM	LINC02272 →	+0.024	+4.039	<.001	.009	3	3
COAD	LINC01248 →	+0.516	+5.516	<.001	.004	3	2
UCEC	ZNF106 →	+0.490	+3.480	.003	.002	3	2
UCEC	TTL →	+0.391	+2.087	.006	.006	3	2
UCEC	ZNF331 →	+0.388	+4.016	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,558 associations by consensus.

RNU6-99P by BECN1 expression — UCEC

Explore this box plot interactively →