BECN1

Across TCGA cell cohorts, BECN1 mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BECN1-associated genes across cancer lineages are N22899-6-C1, Epirubicin, and GSK2801. Each is linked with BECN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BECN1-to-partner and partner-to-BECN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N22899-6-C1 grouped by BECN1-low versus BECN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BECN1→partner) and Y-score (partner→BECN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	N22899-6-C1 →	+0.231	+2.777	.019	.030	3	1
LARGE_INTESTINE	Epirubicin →	+0.656	+2.649	.017	.046	3	1
LARGE_INTESTINE	GSK2801 →	+0.352	+2.871	.019	.021	3	1
LARGE_INTESTINE	Vincristine →	+0.888	+2.871	.030	.021	3	1
LARGE_INTESTINE	LMP744 →	+0.690	+2.871	.031	.021	3	1
LARGE_INTESTINE	Vinorelbine →	+0.682	+2.807	.031	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

N22899-6-C1 by BECN1 expression — LARGE_INTESTINE

Explore this box plot interactively →