BDKRB2

Across TCGA patient cohorts, BDKRB2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BDKRB2-associated genes across cancer lineages are Notch1, ERK2, and MYH11. Each is linked with BDKRB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BDKRB2-to-partner and partner-to-BDKRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by BDKRB2-low versus BDKRB2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BDKRB2→partner) and Y-score (partner→BDKRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Notch1 →	+0.177	+1.887	.010	.029	3	2
SKCM	ERK2 →	+0.194	+1.925	.010	.004	3	1
SKCM	MYH11 →	-0.707	-1.925	.022	.004	3	1
SKCM	AMPK_alpha →	+0.127	+2.906	.011	.001	3	1
SKCM	Src_pY416 →	-0.242	-2.000	.028	.029	3	1
UCEC	EGFR_pY1068 →	-0.353	-4.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Notch1 by BDKRB2 expression — SKCM

Explore this box plot interactively →