BDKRB1

Across TCGA patient cohorts, BDKRB1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BDKRB1-associated genes across cancer lineages are 4E-BP1, C-Raf, and A-Raf_pS299. Each is linked with BDKRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BDKRB1-to-partner and partner-to-BDKRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by BDKRB1-low versus BDKRB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BDKRB1→partner) and Y-score (partner→BDKRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.334	+3.029	.008	.018	3	2
UCEC	C-Raf →	+0.216	+2.321	.001	.034	3	2
UCEC	A-Raf_pS299 →	-0.123	-2.321	.026	.034	3	1
UCEC	FOXO3a_pS318_S321 →	-0.145	-2.312	.012	.034	3	1
UCEC	Notch1 →	+0.213	+2.584	.001	.011	3	1
UCEC	Annexin-1 →	+0.756	+3.019	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

4E-BP1 by BDKRB1 expression — UCEC

Explore this box plot interactively →