BDH2

Across TCGA patient cohorts, BDH2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BDH2-associated genes across cancer lineages are FoxM1, JNK2, and PCNA. Each is linked with BDH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BDH2-to-partner and partner-to-BDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by BDH2-low versus BDH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BDH2→partner) and Y-score (partner→BDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.343	+3.459	.008	.005	3	1
UCEC	JNK2 →	+0.247	+3.459	.013	.005	3	1
UCEC	PCNA →	+0.218	+3.459	.044	.005	3	1
UCEC	STAT3_pY705 →	-0.463	-3.169	<.001	.018	3	1
UCEC	Tuberin_pT1462 →	+0.343	+3.459	.003	.005	3	1
UCEC	Tuberin →	+0.377	+3.459	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FoxM1 by BDH2 expression — UCEC

Explore this box plot interactively →