Across TCGA pan-cancer cohorts, BCRP3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BCRP3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where BCRP3 RNA is repressed in tumor relative to normal tissue. In most cancer types BCRP3 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.
KICH, LUSC, and LUAD are the cancer types where BCRP3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BCRP3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.