BCORL1

Across TCGA pan-cancer cohorts, BCORL1 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated BCORL1 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher BCORL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BCORL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

ESCA, CHOL, and KICH are the cancer types where BCORL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	All	0.198	0.872	.003	18	view →
CHOL	DFS	Median	All	0.045	0.486	.009	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
COAD	OS	Median	IV	0.039	0.660	<.001	12	view →
SCLC	OS	Median	All	0.082	0.822	<.001	12	view →
LUAD	OS	Median	II,III,IV	0.214	0.685	.001	10	view →
ACC	OS	Median	IV	0.145	0.715	<.001	9	view →
HNSC	DFS	Median	II,III,IV	1.000	0.684	.025	8	view →
SKCM	DFS	Median	All	0.336	0.654	<.001	8	view →
KIRP	DFS	Median	All	0.178	0.867	<.001	6	view →
UCEC	DFS	Median	III,IV	0.832	0.519	.035	6	view →
STAD	DFS	Median	III,IV	0.803	0.338	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

BCORL1–ESCA (OS)

Open the ESCA breakdown →