BCO1

Across TCGA patient cohorts, BCO1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCO1-associated genes across cancer lineages are Annexin-1, STAT3_pY705, and Caspase-7-cleavedD198. Each is linked with BCO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCO1-to-partner and partner-to-BCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by BCO1-low versus BCO1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCO1→partner) and Y-score (partner→BCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Annexin-1 →	+0.440	+3.321	.007	.009	3	2
SKCM	STAT3_pY705 →	-0.269	-2.425	.005	.017	3	2
COAD	Caspase-7-cleavedD198 →	+1.136	+2.815	.008	.036	3	2
UCEC	4E-BP1 →	+0.377	+2.029	<.001	.017	3	2
UCEC	Caspase-8 →	-0.233	-2.780	.011	.003	3	2
SKCM	p90 RSK →	+0.168	+1.584	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Annexin-1 by BCO1 expression — SKCM

Explore this box plot interactively →