BCLAF3

Across TCGA patient cohorts, BCLAF3 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCLAF3-associated genes across cancer lineages are PDCD4, eEF2, and eIF4G. Each is linked with BCLAF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both BCLAF3-to-partner and partner-to-BCLAF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by BCLAF3-low versus BCLAF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCLAF3→partner) and Y-score (partner→BCLAF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.442	-1.295	.001	.010	3	3
UCEC	eEF2 →	+0.266	+1.662	.010	.010	3	2
UCEC	eIF4G →	+0.281	+1.999	.001	.002	3	2
UCEC	GAPDH →	+0.396	+1.906	.011	.014	3	2
UCEC	Heregulin →	-0.107	-1.834	.002	.007	3	2
UCEC	Notch1 →	+0.130	+1.524	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

PDCD4 by BCLAF3 expression — UCEC

Explore this box plot interactively →