BCL9

Across TCGA patient cohorts, BCL9 mutation is significantly associated with the RNA expression of many other genes, with 3,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL9-associated genes across cancer lineages are CEP78, PSMB7, and MIR2276. Each is linked with BCL9 in more than 3 cancer types. Because this analysis shows association rather than direction, both BCL9-to-partner and partner-to-BCL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP78 grouped by BCL9-low versus BCL9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL9→partner) and Y-score (partner→BCL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CEP78 →	+0.367	+1.584	.001	<.001	3	4
COAD	PSMB7 →	+0.354	+2.638	<.001	.005	3	4
LGG	MIR2276 →	+0.495	+5.266	<.001	.006	3	3
LIHC	RNU6-921P →	+0.302	+5.902	<.001	.001	3	3
COAD	PHF5A →	+0.441	+2.740	<.001	.002	3	3
UCEC	GNPNAT1 →	+0.401	+1.517	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,015 associations by consensus.

CEP78 by BCL9 expression — UCEC

Explore this box plot interactively →