BCL9

Across TCGA cell cohorts, BCL9 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,164 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BCL9-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Negative regulation of gene expression, epigenetic, and Negative regulation of chromosome condensation. Each is linked with BCL9 in more than 15 cancer types. Because this analysis shows association rather than direction, both BCL9-to-partner and partner-to-BCL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by BCL9-low versus BCL9-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL9→partner) and Y-score (partner→BCL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.074	+1.081	<.001	<.001	3	16
LIVER	Negative regulation of gene expression, epigenetic →	+0.069	+1.000	.003	.001	3	16
BONE	Negative regulation of chromosome condensation →	+0.151	+1.467	<.001	<.001	3	15
STOMACH	Regulation of nucleotide-excision repair →	+0.124	+1.156	<.001	<.001	3	15
STOMACH	Cytoskeleton-dependent intracellular transport →	+0.042	+1.062	<.001	<.001	3	14
SOFT_TISSUE	mRNA 3'-end processing →	+0.064	+0.943	.001	.006	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,164 associations by consensus.

Epigenetic regulation of gene expression by BCL9 expression — BONE

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