BCL9

Across TCGA cell cohorts, BCL9 mutation is significantly associated with the RNA expression of many other genes, with 391 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCL9-associated genes across cancer lineages are POLR1E, CPO, and ME2. Each is linked with BCL9 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL9-to-partner and partner-to-BCL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR1E grouped by BCL9-low versus BCL9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL9→partner) and Y-score (partner→BCL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POLR1E →	+0.440	+2.000	.003	.009	3	2
LARGE_INTESTINE	CPO →	+0.066	+2.040	.006	.001	3	2
LARGE_INTESTINE	ME2 →	+1.042	+2.700	<.001	<.001	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
PANCREAS	OPRPN →	+0.018	+5.000	.001	.006	3	1
SKIN	ACTL9 →	+0.016	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 391 associations by consensus.

POLR1E by BCL9 expression — LARGE_INTESTINE

Explore this box plot interactively →