BCL7A

Across TCGA patient cohorts, BCL7A mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL7A-associated genes across cancer lineages are A-Raf_pS299, INPP4B, and mTOR_pS2448. Each is linked with BCL7A in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL7A-to-partner and partner-to-BCL7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by BCL7A-low versus BCL7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL7A→partner) and Y-score (partner→BCL7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.160	-2.584	.004	.011	3	1
UCEC	INPP4B →	-0.400	-3.321	.007	.010	3	1
UCEC	mTOR_pS2448 →	-0.155	-2.980	.025	.036	3	1
UCEC	p62 Lck ligand →	+0.623	+3.331	<.001	.005	3	1
UCEC	PDK1 →	+0.104	+3.013	.039	.018	3	1
UCEC	VHL →	-1.128	-3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

A-Raf_pS299 by BCL7A expression — UCEC

Explore this box plot interactively →