BCL6B

Across TCGA patient cohorts, BCL6B mutation is significantly associated with the RNA expression of many other genes, with 2,699 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL6B-associated genes across cancer lineages are MTCYBP9, NME9, and IRAK1. Each is linked with BCL6B in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL6B-to-partner and partner-to-BCL6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP9 grouped by BCL6B-low versus BCL6B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL6B→partner) and Y-score (partner→BCL6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTCYBP9 →	+0.163	+4.502	<.001	.007	3	2
UCEC	NME9 →	-0.798	-2.514	<.001	<.001	3	2
UCEC	IRAK1 →	+0.440	+1.752	.004	.004	3	2
UCEC	RPL23AP82 →	+0.453	+1.958	<.001	<.001	3	2
UCEC	CCDC180 →	-0.184	-3.003	.003	<.001	3	2
SKCM	ZNF311 →	-0.745	-3.434	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,699 associations by consensus.

MTCYBP9 by BCL6B expression — LUAD

Explore this box plot interactively →