BCL6B

Across TCGA patient cohorts, BCL6B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL6B-associated genes across cancer lineages are GAPDH, ATM, and EGFR_pY1068. Each is linked with BCL6B in more than 2 cancer types. Because this analysis shows association rather than direction, both BCL6B-to-partner and partner-to-BCL6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by BCL6B-low versus BCL6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL6B→partner) and Y-score (partner→BCL6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.503	+1.807	.006	.025	3	3
UCEC	ATM →	-0.483	-3.571	.002	.002	3	2
UCEC	EGFR_pY1068 →	-0.223	-1.440	.010	.024	3	1
UCEC	eIF4E →	+0.179	+2.169	.014	.003	3	1
UCEC	ERK2 →	+0.176	+2.115	.008	.016	3	1
UCEC	JNK2 →	+0.166	+1.440	.016	.024	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

GAPDH by BCL6B expression — UCEC

Explore this box plot interactively →