BCL6B

Across TCGA cell cohorts, BCL6B mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. CNS shows the largest number of these associations.

The most reproducible BCL6B-associated genes across cancer lineages are FABP12, DPPA5, and KRTAP8-1. Each is linked with BCL6B in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL6B-to-partner and partner-to-BCL6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FABP12 grouped by BCL6B-low versus BCL6B-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL6B→partner) and Y-score (partner→BCL6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FABP12 →	+0.116	+4.981	.002	.008	3	2
CNS	DPPA5 →	+0.040	+4.981	<.001	.008	3	1
LUNG_SCLC	KRTAP8-1 →	+0.073	+5.643	<.001	.002	3	1
LUNG_SCLC	OR2T2 →	+0.023	+5.643	<.001	.002	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FABP12 by BCL6B expression — CNS

Explore this box plot interactively →