BCL3

Across TCGA pan-cancer cohorts, BCL3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BCL3 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher BCL3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BCL3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where BCL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.507	0.930	.004	32	view →
PDAC	OS	Median	II,III,IV	0.981	0.702	.004	6	view →
GBM	DFS	Quartile	All	0.509	0.850	.008	5	view →
LSCC	OS	Tertile	II,III,IV	0.617	0.901	.027	5	view →
LUAD	DFS	Median	All	1.000	0.891	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BCL3–CCRCC (DFS)

Open the CCRCC breakdown →