BCL3

Across TCGA patient cohorts, BCL3 mutation is significantly associated with the RNA expression of many other genes, with 609 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL3-associated genes across cancer lineages are RNU2-61P, RN7SKP192, and IGHD6-13. Each is linked with BCL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL3-to-partner and partner-to-BCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-61P grouped by BCL3-low versus BCL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL3→partner) and Y-score (partner→BCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU2-61P →	+0.307	+3.299	.005	.001	3	2
SKCM	RN7SKP192 →	+0.079	+3.422	<.001	.006	3	2
CESC	IGHD6-13 →	+1.755	+4.816	<.001	.003	3	2
UCEC	RNA5SP405 →	+0.400	+3.707	<.001	.002	3	2
COAD	SCG5-AS1 →	+0.449	+3.446	<.001	.009	3	2
CESC	RN7SL255P →	+0.261	+5.507	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 609 associations by consensus.

RNU2-61P by BCL3 expression — UCEC

Explore this box plot interactively →