BCL3

Across TCGA patient cohorts, BCL3 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL3-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and Myosin-IIa. Each is linked with BCL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL3-to-partner and partner-to-BCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by BCL3-low versus BCL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL3→partner) and Y-score (partner→BCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.200	-2.446	.014	.020	3	1
UCEC	Ku80 →	+0.384	+3.179	<.001	.010	3	1
UCEC	Myosin-IIa →	+0.210	+2.818	.024	.035	3	1
UCEC	p62 Lck ligand →	+0.421	+2.179	.007	.034	3	1
UCEC	p70-S6K_pT389 →	-0.229	-2.990	.012	.036	3	1
UCEC	p70-S6K →	+0.241	+3.189	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

JNK_pT183_Y185 by BCL3 expression — UCEC

Explore this box plot interactively →