BCL2L14

Across TCGA patient cohorts, BCL2L14 mutation is significantly associated with the RNA expression of many other genes, with 966 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL2L14-associated genes across cancer lineages are KLC2, SDHA, and PDRG1. Each is linked with BCL2L14 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2L14-to-partner and partner-to-BCL2L14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLC2 grouped by BCL2L14-low versus BCL2L14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2L14→partner) and Y-score (partner→BCL2L14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KLC2 →	+0.418	+3.467	.008	.002	3	2
UCEC	SDHA →	+0.704	+2.625	<.001	.005	3	2
UCEC	PDRG1 →	+0.531	+3.459	.002	.005	3	2
BRCA	UBE2V1P8 →	+0.193	+6.571	<.001	.001	3	2
UCEC	RPS29P32 →	+0.515	+2.462	<.001	.004	3	2
HNSC	RNA5SP424 →	+0.310	+6.468	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 966 associations by consensus.

KLC2 by BCL2L14 expression — UCEC

Explore this box plot interactively →