BCL2L13

Across TCGA patient cohorts, BCL2L13 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL2L13-associated genes across cancer lineages are EGFR, JNK_pT183_Y185, and MEK1. Each is linked with BCL2L13 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2L13-to-partner and partner-to-BCL2L13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by BCL2L13-low versus BCL2L13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2L13→partner) and Y-score (partner→BCL2L13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.221	-2.321	.005	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.190	-2.308	.024	.036	3	1
UCEC	MEK1 →	+0.474	+2.321	.009	.035	3	1
UCEC	mTOR_pS2448 →	-0.193	-2.986	.010	.035	3	1
UCEC	Myosin-IIa →	+0.196	+2.177	.043	.035	3	1
UCEC	Notch1 →	+0.154	+2.817	.029	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR by BCL2L13 expression — UCEC

Explore this box plot interactively →