BCL2L12

Across TCGA patient cohorts, BCL2L12 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible BCL2L12-associated genes across cancer lineages are 4E-BP1_pS65, EGFR_pY1173, and IGFBP2. Each is linked with BCL2L12 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2L12-to-partner and partner-to-BCL2L12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pS65 grouped by BCL2L12-low versus BCL2L12-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2L12→partner) and Y-score (partner→BCL2L12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1_pS65 →	+0.238	+2.321	.003	.006	3	2
SKCM	EGFR_pY1173 →	-0.116	-3.309	.002	.009	3	1
SKCM	IGFBP2 →	-0.533	-2.321	.011	.006	3	1
SKCM	p90 RSK →	+0.329	+3.459	<.001	.004	3	1
SKCM	PCNA →	+0.176	+3.321	.026	.009	3	1
SKCM	PDCD4 →	-0.415	-1.807	.011	.026	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

4E-BP1_pS65 by BCL2L12 expression — SKCM

Explore this box plot interactively →