BCL2L12

Across TCGA cell cohorts, BCL2L12 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BCL2L12-associated genes across cancer lineages are COX4I2, CXorf51B, and ELOA3DP. Each is linked with BCL2L12 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2L12-to-partner and partner-to-BCL2L12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX4I2 grouped by BCL2L12-low versus BCL2L12-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2L12→partner) and Y-score (partner→BCL2L12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COX4I2 →	+0.088	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	CXorf51B →	+1.088	+5.228	.002	.005	3	1
LARGE_INTESTINE	ELOA3DP →	+0.039	+4.273	<.001	.006	3	1
LARGE_INTESTINE	OR13G1 →	+0.024	+4.415	<.001	.007	3	1
LARGE_INTESTINE	WNT8A →	+0.028	+5.217	<.001	<.001	3	1
BLOOD_Leukemia	PLA2G4D →	+0.046	+4.669	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

COX4I2 by BCL2L12 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →