BCL2L11

Across TCGA patient cohorts, BCL2L11 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL2L11-associated genes across cancer lineages are mTOR_pS2448, ASNS, and Caspase-7-cleavedD198. Each is linked with BCL2L11 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2L11-to-partner and partner-to-BCL2L11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by BCL2L11-low versus BCL2L11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2L11→partner) and Y-score (partner→BCL2L11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.121	-2.680	.019	.006	3	2
UCEC	ASNS →	+0.362	+2.115	.003	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.485	+1.697	.018	.012	3	2
UCEC	4E-BP1 →	+0.312	+4.029	<.001	<.001	3	2
UCEC	C-Raf →	+0.164	+2.222	<.001	.010	3	2
UCEC	eIF4E →	+0.218	+2.598	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

mTOR_pS2448 by BCL2L11 expression — UCEC

Explore this box plot interactively →