BCL2L11

Across TCGA cell cohorts, BCL2L11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,310 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible BCL2L11-associated GO terms across cancer lineages are Regulation of organelle assembly, Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, and Epigenetic regulation of gene expression. Each is linked with BCL2L11 in more than 11 cancer types. Because this analysis shows association rather than direction, both BCL2L11-to-partner and partner-to-BCL2L11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of organelle assembly grouped by BCL2L11-low versus BCL2L11-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2L11→partner) and Y-score (partner→BCL2L11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of organelle assembly →	+0.061	+1.009	<.001	<.001	3	12
LUNG_SCLC	Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.141	+1.140	<.001	<.001	3	11
SOFT_TISSUE	Epigenetic regulation of gene expression →	+0.053	+0.929	.002	<.001	3	11
SOFT_TISSUE	Regulation of mRNA stability →	+0.061	+1.004	.001	<.001	3	11
STOMACH	Positive regulation of myoblast differentiation →	+0.126	+1.117	.006	.004	3	11
SOFT_TISSUE	Positive regulation of DNA repair →	+0.065	+0.758	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,310 associations by consensus.

Regulation of organelle assembly by BCL2L11 expression — LUNG_SCLC

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