BCL2L1

Across TCGA patient cohorts, BCL2L1 mutation is significantly associated with the RNA expression of many other genes, with 999 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL2L1-associated genes across cancer lineages are HLFP1, LINC01162, and CSAG4. Each is linked with BCL2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2L1-to-partner and partner-to-BCL2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HLFP1 grouped by BCL2L1-low versus BCL2L1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2L1→partner) and Y-score (partner→BCL2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HLFP1 →	+0.069	+5.000	<.001	.003	3	2
LUAD	LINC01162 →	+0.500	+3.659	.001	.009	3	2
LUAD	CSAG4 →	+1.509	+3.839	<.001	.009	3	2
LUAD	RNU6-210P →	+0.357	+4.802	.001	.001	3	2
LUSC	MIR370 →	+0.378	+5.337	.003	.006	3	2
LUSC	FAM230F →	+0.123	+6.438	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 999 associations by consensus.

HLFP1 by BCL2L1 expression — LUAD

Explore this box plot interactively →