BCL2L1

Across TCGA patient cohorts, BCL2L1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL2L1-associated genes across cancer lineages are eIF4E, MEK1, and p62 Lck ligand. Each is linked with BCL2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2L1-to-partner and partner-to-BCL2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by BCL2L1-low versus BCL2L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2L1→partner) and Y-score (partner→BCL2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.247	+3.169	.015	.019	2	2
UCEC	MEK1 →	+0.425	+3.321	.016	.010	3	1
UCEC	p62 Lck ligand →	+0.386	+2.459	.014	.020	3	1
UCEC	PCNA →	+0.290	+3.321	.005	.010	3	1
UCEC	Rab25 →	-0.397	-3.169	.013	.019	3	1
UCEC	Rad50 →	-0.310	-2.459	.008	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eIF4E by BCL2L1 expression — UCEC

Explore this box plot interactively →