BCL2

Across TCGA patient cohorts, BCL2 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,905 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible BCL2-associated proteins across cancer lineages are EIF4G1, ERO1A, and PGAM1_S31. Each is linked with BCL2 in more than 6 cancer types. Because this analysis shows association rather than direction, both BCL2-to-partner and partner-to-BCL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BCL2 versus EIF4G1 in OV, with a Pearson correlation of -0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2→partner) and Y-score (partner→BCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EIF4G1 →	-0.312	-1.127	<.001	<.001	3	7
LSCC	ERO1A →	-0.635	-0.783	<.001	<.001	3	7
HNSC	PGAM1_S31 →	-0.619	-0.972	<.001	<.001	3	6
OV	CDKN1B →	+0.481	+0.716	<.001	<.001	3	6
OV	HDLBP_S944 →	-0.651	-0.660	.001	.005	3	6
PDAC	YME1L1 →	-0.332	-0.502	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,905 associations by consensus.

BCL2 vs EIF4G1 — OV

Explore this scatter interactively →